Beilstein J. Org. Chem.2024,20, 540–551, doi:10.3762/bjoc.20.46
show good acyl-ACPthioesterase inhibition in line with strong herbicidal activity against commercially important weeds in broadacre crops, e.g., wheat and corn. The desired substituted 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines were prepared via an optimized BH3-mediated reduction involving tris
-dihydro[1,3]thiazolo[4,5-b]pyridine; acyl-ACPthioesterase; bioisostere; herbicide; heterocycle; Introduction
The presence of weed infestations exerts a high strain on food production around the globe by depleting resources for the crops and facilitating the transmission of diseases [1]. Although
with emphasis on the structural diversity of small-molecule ligands. In this context, acyl-acyl carrier protein (acyl-ACP) thioesterase inhibitors have shown a remarkable variability. Fatty acid thioesterase (FAT) enzymes represent a family of proteins exclusively found in higher plants. They mediate
PDF
Graphical Abstract
Scheme 1:
Selected known inhibitors 1–3 of acyl-ACP thioesterases (belonging to the protein family of FATs) a...